Inspired by classic and contemporary speculative fiction, Buffalo Is the New Buffalo explores science fiction tropes through a Métis lens: a Two-Spirit rougarou (shapeshifter) in the nineteenth century tries to solve a murder in her community and joins the nêhiyaw-pwat (Iron Confederacy) in order to successfully stop Canadian colonial expansion into the West. A Métis man is gored by a radioactive bison, gaining super strength, but losing the ability to be remembered by anyone not related to him by blood. Nanites babble to babies in Cree, virtual reality teaches transformation, foxes take human form and wreak havoc on hearts, buffalo roam free, and beings grapple with the thorny problem of healing from colonialism.